所选辐射防护剂的行为毒性。

Behavioral toxicity of selected radioprotectors.

作者信息

Landauer M R, Davis H D, Kumar K S, Weiss J F

机构信息

Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5245, USA.

出版信息

Adv Space Res. 1992;12(2-3):273-83. doi: 10.1016/0273-1177(92)90117-g.

DOI:10.1016/0273-1177(92)90117-g

PMID:11537018

Abstract

Effective radioprotection with minimal behavioral disruption is essential for the selection of protective agents to be used in manned spaceflight. This overview summarizes the studies on the behavioral toxicity of selected radioprotectors classified as phosphorothioates (WR-2721, WR-3689), bioactive lipids (16, 16 dimethylprostaglandin E2(DiPGE2), platelet activating factor (PAF), leukotriene C4), and immunomodulators (glucan, synthetic trehalose dicorynomycolate, and interleukin-1). Behavioral toxicity was examined in laboratory mice using a locomotor activity test. For all compounds tested, there was a dose-dependent decrease in locomotor behavior that paralleled the dose-dependent increase in radioprotection. While combinations of radioprotective compounds (DiPGE2 plus WR-2721) increased radioprotection, they also decreased locomotor activity. The central nervous system stimulant, caffeine, was able to mitigate the locomotor decrement produced by WR-3689 or PAF.

摘要

在载人航天中，选择能提供有效辐射防护且对行为干扰最小的防护剂至关重要。本综述总结了对选定辐射防护剂行为毒性的研究，这些防护剂分为硫代磷酸酯类（WR - 2721、WR - 3689）、生物活性脂质类（16, 16 - 二甲基前列腺素E2（DiPGE2）、血小板活化因子（PAF）、白三烯C4）和免疫调节剂类（葡聚糖、合成海藻糖二分枝菌酸酯和白细胞介素 - 1）。使用运动活动测试在实验室小鼠中检测行为毒性。对于所有测试的化合物，运动行为呈剂量依赖性下降，这与辐射防护的剂量依赖性增加平行。虽然辐射防护化合物组合（DiPGE2加WR - 2721）增加了辐射防护效果，但它们也降低了运动活性。中枢神经系统兴奋剂咖啡因能够减轻WR - 3689或PAF产生的运动能力下降。