Gregoriadis G, Neerunjun E D
Res Commun Chem Pathol Pharmacol. 1975 Feb;10(2):351-62.
The possibility of employing liposome-entrapped actinomycin D for the treatment of AKR mice inoculated with AKR-A cells was examined. It was found that injection of actinomycin D after its entrapment in liposomes prolonged the survival of such mice to a greater extent than did similar amounts of free actinomycin D. Data from in vitro experiments suggest that entrapped actinomycin D could localize in the nucleus of AKR-A cells presumably following endocytosis of the liposomal carrier and subsequent liberation of the drug in, and its diffusion from, the lysosomes.
研究了采用脂质体包裹的放线菌素D治疗接种AKR - A细胞的AKR小鼠的可能性。结果发现，脂质体包裹后的放线菌素D注射比等量游离放线菌素D能更大程度地延长此类小鼠的存活时间。体外实验数据表明，包裹的放线菌素D可能在脂质体载体被内吞后，在溶酶体中释放并扩散，从而定位于AKR - A细胞的细胞核中。
