Boise State University, Department of Biological Sciences, 1910 University Dr, Boise, ID 83725, USA.
Expert Opin Drug Deliv. 2010 Sep;7(9):1063-77. doi: 10.1517/17425247.2010.502560.
Metal oxide nanoparticles, including zinc oxide, are versatile platforms for biomedical applications and therapeutic intervention. There is an urgent need to develop new classes of anticancer agents, and recent studies demonstrate that ZnO nanomaterials hold considerable promise.
This review analyzes the biomedical applications of metal oxide and ZnO nanomaterials under development at the experimental, preclinical and clinical levels. A discussion regarding the advantages, approaches and limitations surrounding the use of metal oxide nanoparticles for cancer applications and drug delivery is presented. The scope of this article is focused on ZnO, and other metal oxide nanomaterial systems, and their proposed mechanisms of cytotoxic action, as well as current approaches to improve their targeting and cytotoxicity against cancer cells.
This review aims to give an overview of ZnO nanomaterials in biomedical applications.
Through a better understanding of the mechanisms of action and cellular consequences resulting from nanoparticles interactions with cells, the inherent toxicity and selectivity of ZnO nanoparticles against cancer may be improved further to make them attractive new anticancer agents.
金属氧化物纳米粒子，包括氧化锌，是生物医学应用和治疗干预的多功能平台。迫切需要开发新类别的抗癌药物，最近的研究表明，氧化锌纳米材料具有很大的潜力。
本综述分析了金属氧化物和 ZnO 纳米材料在实验、临床前和临床水平的生物医学应用。讨论了使用金属氧化物纳米粒子进行癌症应用和药物输送的优点、方法和局限性。本文的范围集中在 ZnO 及其他金属氧化物纳米材料系统，以及它们提出的细胞毒性作用机制，以及目前改善其针对癌细胞的靶向性和细胞毒性的方法。
本综述旨在概述 ZnO 纳米材料在生物医学中的应用。
通过更好地了解纳米粒子与细胞相互作用导致的作用机制和细胞后果，可以进一步提高 ZnO 纳米粒子对癌症的固有毒性和选择性，使它们成为有吸引力的新型抗癌药物。
