Pollay M
Res Commun Chem Pathol Pharmacol. 1975 Apr;10(4):763-6.
The blood-brain barrier (BBB) in one cerebral hemisphere of rabbit was damaged by the ipsilateral infusion of hypertonic (3 Molar) urea into the carotid artery. Using the indicator diffusion technique, the clearance of the glycine (by simple diffusion) and phenylalanine molecule (by facilitated diffusion) was enhanced in the urea infused cerebral hemisphere. The experimental methodology is a nondestructive and sensitive method for evaluating the integrity of the BBB.
通过向兔的一侧颈动脉同侧注入高渗（3摩尔）尿素，破坏其一个大脑半球的血脑屏障。采用示踪扩散技术，在注入尿素的大脑半球中，甘氨酸（通过简单扩散）和苯丙氨酸分子（通过易化扩散）的清除率提高。该实验方法是一种用于评估血脑屏障完整性的非破坏性且灵敏的方法。
