Clavert A
Arch Anat Histol Embryol. 1978;61:89-142.
The analysis of duplicate embryos, cyclops and colobomic fissure defects show that: 1. - optic vesicle and colobomic fissure are inducted by the prechordal plate. The combined inductive influence of prechordal plate and notochord carry eye absence out; 2. - initial failure of the colobomic fissure is always associated with retina folds and produce lens, vitreous and optic nerve anomalies; 3. - colobomic fissure is one indispensable anatomic structure to the optic fiber migration from the retina to the optic pedicle. Retina cutting in 4 days old chick embryos determine the disappearing of the pedicle cells. Contact between the optic fiber and the pedicle cells determine the glial cells differentiation. The colobomic fissure is a very important period of the eye evolution and the eye organisation.
对重复胚胎、独眼畸形和脉络膜裂缺损的分析表明：1. - 视泡和脉络膜裂由口前板诱导。口前板和脊索的联合诱导作用导致无眼；2. - 脉络膜裂的初始失败总是与视网膜褶皱相关，并产生晶状体、玻璃体和视神经异常；3. - 脉络膜裂是视神经从视网膜向视蒂迁移不可或缺的解剖结构。在4日龄鸡胚中切断视网膜会导致视蒂细胞消失。视神经纤维与视蒂细胞的接触决定了神经胶质细胞的分化。脉络膜裂是眼睛进化和眼组织形成的一个非常重要的时期。
