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低温保存与空间医学

Low temperature preservation and space medicine.

作者信息

Segall P E, Sternberg H, Waitz H D

机构信息

BioTime, Inc., Berkeley, CA 94710, USA.

出版信息

J Gravit Physiol. 1995;2(1):P143-4.

PMID:11538902
Abstract

Cold maintenance may be an option for compromised space-borne astronauts. Contemporary aneurysm surgery can involve cooling below 20 degrees C for nearly one hour. Dogs and baboons have survived blood-substituted hypothermia for 1-3 hours. Hamsters have recovered from partial-freezing below -1 degree C, and supercooling at -5 degrees C. Laboratory frogs have survived partial-freezing from -9 degrees C, while in nature, frogs may overwinter in these states. While some invertebrates can tolerate freezing to cryogenic temperatures, no vertebrate has survived complete freezing. The following studies (hypothermia and sub-zero experiments) were conducted to explore low temperature preservation of rodents, dogs and baboons.

摘要

对于身体状况不佳的太空宇航员来说,低温维持可能是一种选择。当代动脉瘤手术可能涉及将体温降至20摄氏度以下近一小时。狗和狒狒在血液替代低温状态下存活了1至3小时。仓鼠在零下1摄氏度以下的局部冷冻以及零下5摄氏度的过冷状态后恢复。实验室中的青蛙在零下9摄氏度的局部冷冻中存活,而在自然环境中,青蛙可能以这些状态越冬。虽然一些无脊椎动物可以耐受冷冻至低温,但没有脊椎动物能在完全冷冻后存活。进行了以下研究(低温及零下实验)以探索啮齿动物、狗和狒狒的低温保存。

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