Louisy F, Schroiff P, Guezennec C Y, Güell A
Institut de Médecine Aérospatiale du Service de Santé des Armées, Brétigny sur Orge, France.
J Gravit Physiol. 1995;2(1):P15-6.
Exposure to actual or simulated microgravity is known to result in changes in lower limb venous compliance or distensibility which may play a role in post-bedrest or postflight orthostatic intolerance. Venous deconditioning has only been described in terms of changes in vascular compliance or distensibility. But a complete understanding of changes in venous hemodynamics and cardiovascular regulation occurring under these conditions has to take into account changes in emptying capacities of the veins which influence venous return, cardiac filling, and cardiac output regulation. Moreover, few data are available about the course of changes in venous hemodynamics for periods of simulated microgravity longer than 4 weeks. The purpose of this investigation was to measure parameters of venous compliance and venous emptying before, during, and after a 42-day period of bedrest at -6 degrees head-down tilt for a better understanding of long term venous physiological adaptation to microgravity.
已知暴露于实际或模拟微重力环境会导致下肢静脉顺应性或扩张性发生变化，这可能在卧床休息后或飞行后直立不耐受中起作用。静脉功能失调仅根据血管顺应性或扩张性的变化来描述。但是，要全面了解在这些条件下发生的静脉血流动力学和心血管调节变化，必须考虑到静脉排空能力的变化，这些变化会影响静脉回流、心脏充盈和心输出量调节。此外，关于超过4周的模拟微重力期间静脉血流动力学变化过程的数据很少。本研究的目的是测量在-6度头低位卧床42天期间及前后的静脉顺应性和静脉排空参数，以便更好地了解静脉对微重力的长期生理适应。
