Louisy F, Guezennec C Y, Güell A
Centre d'Etudes et de Recherches de Médecine Aérospatiale, Brétigny sur Orge.
J Gravit Physiol. 1994 May;1(1):P29-30.
The mechanisms underlying increased venous distensibility during exposure to microgravity are not well known yet. However, there seems to be evidence indicating that skeletal muscle changes resulting from exposure to microgravity play a very important role. The purpose of this experiment was to test the hypothesis that leg muscles could play an important role in the changes of leg venous distensibility observed in simulated microgravity. Twelve subjects were submitted for 28 days to a -6 degrees head-down bedrest. Changes in leg vein hemodynamics (filling and emptying) have been measured by mercury strain gauge plethysmography with venous occlusion. Six of these subjects trained their lower limbs with isometric and isokinetic exercises during bedrest (group CM), while the other 6 subjects (control group, C) had no training.
暴露于微重力环境下静脉扩张性增加的潜在机制尚不明确。然而，似乎有证据表明，暴露于微重力环境导致的骨骼肌变化起着非常重要的作用。本实验的目的是检验以下假设：在模拟微重力环境下观察到的腿部静脉扩张性变化中，腿部肌肉可能起重要作用。12名受试者接受了为期28天的 -6度头低位卧床休息。通过带有静脉阻塞的水银应变片体积描记法测量腿部静脉血流动力学（充盈和排空）的变化。其中6名受试者在卧床休息期间通过等长和等动运动训练下肢（CM组），而另外6名受试者（对照组，C组）未进行训练。
