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[急性肾动脉闭塞。病因、诊断及治疗方法]

[Acute renal artery occlusion. Origin, diagnosis, possibilities of treatment].

作者信息

Buri P

出版信息

Schweiz Med Wochenschr. 1975 Jul 26;105(30):941-8.

PMID:1153993
Abstract

Although acute renal artery occlusion is luckily a rare event, many cases are probably overlooked. They are caused either by emboli, accidents or iatrogenic vascular injury. The conventional wisdom holds that the kidney is irreversibly damaged by arterial obstruction lasting several hours, but clinical experience shows that there are exceptions to this rule. How this is to be explained from the pathophysiologic viewpoint is discussed in this article. Recognition of acute renal artery occlusion is easiest and fastest in iatrogenic cases. In trauma due to accidents, useful pointers are hematuria, site and intensity of the injuring force and concomitant lesions. Emboli do not give rise to specific symptoms and are most to be suspected in cases prone to embolism. It is helpful to subdivide renal artery occlusions into two groups, one with and the other without mural lesionsof the artery. The outlook is a priori considerably better in cases with intact vascular wall. Here, i.e. in the presence of fresh or recent thrombo-embolic occlusion, surgery is most likely to prove successful, but conservative management alone is known to afford good results too. A differentiated approach to treatment is outlined. Severe vascular trauma may confront the surgeon with virtually insoluble problems, but the conditions under which surgical intervention is nonetheless recommended are defined. Generally the presence of a normal conttalateral kidney will lessen the need for surgical action. Surgery is however mandatory in the none too rare case of bilateral renal artery occlusion or when a solitary kidney is affected. In these cases in-situ perfusion combined with organ cooling, explantation, reconstructive surgery extra vivum and heterotopic re-implantation (for instance into the pelvis) is a most promising procedure.

摘要

尽管急性肾动脉闭塞幸好是一种罕见的情况,但许多病例可能被忽视了。它们是由栓子、外伤或医源性血管损伤引起的。传统观点认为,肾脏会因持续数小时的动脉阻塞而不可逆转地受损,但临床经验表明,这条规则也有例外。本文将从病理生理学角度探讨如何解释这种情况。在医源性病例中,急性肾动脉闭塞最容易且最快被识别。在意外创伤中,有用的线索包括血尿、致伤力的部位和强度以及伴随的损伤。栓子不会引起特定症状,在容易发生栓塞的病例中最应怀疑。将肾动脉闭塞分为两组是有帮助的,一组是动脉有壁层病变的,另一组是没有壁层病变的。血管壁完整的病例,其预后在理论上要好得多。在这里,即在存在新鲜或近期血栓 - 栓塞性闭塞的情况下,手术最有可能成功,但仅保守治疗也已知能取得良好效果。本文概述了一种有区别的治疗方法。严重的血管创伤可能使外科医生面临几乎无法解决的问题,但也明确了推荐手术干预的条件。一般来说,对侧肾脏正常会减少手术的必要性。然而,在双侧肾动脉闭塞这种并非罕见的情况或单肾受影响时,手术是必须的。在这些情况下,原位灌注结合器官冷却、切除、体外重建手术和异位再植(例如植入盆腔)是一种非常有前景的方法。

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