Stricker E M, Friedman M I, Zigmond M J
Science. 1975 Sep 12;189(4206):895-7. doi: 10.1126/science.1154028.
Rats given intravenricular injections of 6-hydroxydopamine or bilateral electrolytic lesions of the lateral hypothalamus do not show the normal increase in food intake in response to large decreases in glucose utilization or exposure to severe cold stress. However, they will eat more during chronic glucoprivation that is less intense, or during exposure to more moderate cold stress. Thus, the feeding deficits of these lesioned rats may not reflect an inability to respond to certain qualitatively different stimuli, but rather an inability to respond to quantitatively different intensities of the same stimulus.
给大鼠脑室内注射6-羟基多巴胺或对下丘脑外侧进行双侧电解损伤后，当葡萄糖利用率大幅下降或暴露于严重冷应激时，它们不会出现正常的进食量增加。然而，在程度较轻的慢性糖剥夺期间，或暴露于较为温和的冷应激期间，它们会吃得更多。因此，这些损伤大鼠的进食缺陷可能并非反映出无法对某些性质不同的刺激做出反应，而是无法对同一刺激的不同强度做出定量反应。
