Snyder G L, Stricker E M
Behav Neurosci. 1985 Apr;99(2):310-22. doi: 10.1037//0735-7044.99.2.310.
Lateral hypothalamic damage impaired both physiological and behavioral responses of rats during exposure to a 5 degree C environment. The brain-damaged animals usually did not conserve heat in the cold as well as control rats did, nor did they always increase their caloric intake to meet their energy needs. However, when given sucrose solution to drink instead of water, they did increase their ingestion of chow in response to cold exposure. It is likely that the elevated consumption of palatable fluid served to relieve dehydration and thereby removed its constraints on eating, thus permitting hyperphagia to occur. In contrast to these results, rats with large dopamine-depleting brain lesions, produced by intraventricular 6-hydroxydopamine treatments, always increased food intake when exposed to cold stress and demonstrated no apparent problems in peripheral vasoconstriction. Thus, it is unlikely that striatal dopamine depletions account for either the impaired feeding response or the inadequate heat conservation of rats with lateral hypothalamic lesions during cold stress.
下丘脑外侧损伤会损害大鼠在5摄氏度环境中的生理和行为反应。脑损伤动物在寒冷环境中通常不像对照大鼠那样能很好地保存热量，它们也不总是增加热量摄入以满足能量需求。然而，当给它们蔗糖溶液饮用而非水时，它们确实会因暴露于寒冷环境而增加食物摄入量。很可能美味液体的摄入量增加有助于缓解脱水，从而消除其对进食的限制，进而导致过度进食。与这些结果相反，经脑室内注射6-羟基多巴胺处理导致多巴胺大量耗竭性脑损伤的大鼠，在暴露于冷应激时总是会增加食物摄入量，并且在外周血管收缩方面没有明显问题。因此，纹状体多巴胺耗竭不太可能是下丘脑外侧损伤大鼠在冷应激期间进食反应受损或热量保存不足的原因。
