Zheng S, Qian W, Wang B, Shi X, Liang Z, Hu Z
Institute of Space Medico-Engineering, Beijing, China.
Space Med Med Eng (Beijing). 1997 Oct;10(5):333-6.
To study the effects of sustained intensive noise on rats, fifty SD male rats were randomly divided into: control group and 1 d, 3 d, 7 d and 14 d noise exposure groups (120 dBSPL, broadband noise, 2 h daily). The results showed that after noise exposure, the ACTH level and the corticosterone level in serum increased, but the content of DA in diencephalon decreased, the weight of adrenal gland increased, while that of thymus and spleen decreased. Change of weight of adrenal gland and thymus became maximum after 7d-exposure. The ACTH level in serum and the content of DA in diencephalon decreased and the later reached the lowest value and the weight of adrenal gland and thymus returned to normal level after 14 d exposure. It indicated that the acute response began to decrease after 7d-exposure, and the response turned into a chronic inhibitory state after 14d-exposure.
为研究持续高强度噪声对大鼠的影响，将50只雄性SD大鼠随机分为：对照组以及1天、3天、7天和14天噪声暴露组（120 dBSPL，宽带噪声，每天2小时）。结果显示，噪声暴露后，血清中促肾上腺皮质激素（ACTH）水平和皮质酮水平升高，但间脑中多巴胺（DA）含量降低，肾上腺重量增加，而胸腺和脾脏重量降低。肾上腺和胸腺重量变化在暴露7天后达到最大。暴露14天后，血清中ACTH水平和间脑中DA含量降低，后者降至最低值，肾上腺和胸腺重量恢复正常水平。这表明暴露7天后急性反应开始减弱，暴露14天后反应转为慢性抑制状态。
