[二十八烷醇对尾部悬吊大鼠食物生理参数的影响]

[Effects of octacosanol in food physiological parameters in tail-suspended rats].

作者信息

Bai S, Xie L, Liu C, Zheng Q, Chen J

机构信息

Institute of Space Medico-Engineering, Beijing, China.

出版信息

Space Med Med Eng (Beijing). 1997 Dec;10(6):450-2.

PMID:11540445

Abstract

The purposes of the experiment were to observe the physiological effects of octacosanol in food on tail-suspended rats and to investigate the possibility of using octacosanol in health food for astronauts. 24 male Wistar rats were randomly divided into free action control, tail-suspension and tail suspension plus octacosanol (TSO) groups. Octacosanol was emulsified into water by supersound and given to TSO rats with a dosage of 25 mg/kg wt d. The results showed that octacosanol elevated the weight of thymus, improved biomechanical properties of the femur and improved membrane fluidity of red blood cell. It suggests that octacosanol can counteract some effects of simulated weightlessness on rats. Therefore, octacosanol may be added to natural foods to benefit the health of cosmonauts.

摘要

该实验的目的是观察食物中二十八烷醇对尾部悬吊大鼠的生理影响，并研究在宇航员保健食品中使用二十八烷醇的可能性。将24只雄性Wistar大鼠随机分为自由活动对照组、尾部悬吊组和尾部悬吊加二十八烷醇（TSO）组。通过超声将二十八烷醇乳化于水中，以25 mg/kg体重·天的剂量给予TSO组大鼠。结果表明，二十八烷醇可提高大鼠胸腺重量，改善股骨的生物力学性能，并改善红细胞膜流动性。这表明二十八烷醇可以抵消模拟失重对大鼠的一些影响。因此，可将二十八烷醇添加到天然食物中以有益于宇航员的健康。