Sugiyama Y, Matsukawa T, Inamura K, Zaman A S, Mano T
Department of Autonomic and Behavioral Neurosciences, Nagoya University, Japan.
Environ Med. 1995 Aug;39(1):81-4.
To clarify the neural mechanisms involved in blood pressure regulation during head-up tilting (HUT), arterial baroreflex controls for heart rate and muscle sympathetic nerve activity (MSNA) were evaluated by applying frequency transfer function and coherence analyses to the equidistant time series data of RR-interval, MSNA and mean blood pressure during graded HUT in six healthy subjects. Coherence analysis indicated that the RR-interval and MSNA were linked linearly with mean blood pressure in the low (0.07-0.12 Hz) and high (0.23-0.27 Hz) frequency domains. Arterial baroreflex gain for the heart rate decreased significantly during HUT, while the baroreflex gain for MSNA showed no significant change. These results indicate that the preserved arterial baroreflex gain for MSNA plays an important role in maintaining blood pressure during orthostasis.
为阐明头高位倾斜（HUT）期间血压调节所涉及的神经机制，通过对6名健康受试者在分级HUT期间RR间期、肌肉交感神经活动（MSNA）和平均血压的等距时间序列数据应用频率传递函数和相干分析，评估了心率和MSNA的动脉压力反射控制。相干分析表明，RR间期和MSNA在低频（0.07 - 0.12 Hz）和高频（0.23 - 0.27 Hz）域与平均血压呈线性相关。HUT期间心率的动脉压力反射增益显著降低，而MSNA的压力反射增益无显著变化。这些结果表明，MSNA保留的动脉压力反射增益在维持直立姿势期间的血压方面起重要作用。
