[家兔 +Gz 暴露过程中心脏功能的变化]

[Changes of cardiac function during +Gz exposure in rabbits].

作者信息

Sun X, Cai J, Liu Y, Xue L, Sun H

机构信息

Department of Aerospace Biodynamics, Fourth Military Medical University, Xi'an, China.

出版信息

Space Med Med Eng (Beijing). 1997 Aug;10(4):250-3.

PMID:11540558

Abstract

Changes of cardiac function was studied during +Gz exposure in rabbits. Seven New Zealand rabbits were anesthetized and exposed to +2, +4, and +6 Gz (each for 30s, onset rate 1G/s, with 15 min interval in between). The left ventricular systolic pressure (LVSP), peak rate of left ventricular pressure rising (+dp/dtmax) and ECG were recorded. The results showed that during +2, +4 and +6 Gz exposures, LVSP decreased by 62.96% (P<0.01), 63.34% (P<0.01) and 82.01% (P<0.01) respectively, and +dp/dtmax decreased by 58.46% (P<0.01), 53.59% (P<0.01) and 63.06% (P<0.01) respectively, and the left ventricular end diastolic pressure decreased by 67.78 % (P>0.05), 332.74 % (P<0.01) and 500.54% (P<0.01) respectively, as compared with those of control. It is suggested that cardiac function is depressed with +Gz exposure.

摘要

研究了家兔在 +Gz 暴露过程中心脏功能的变化。将 7 只新西兰家兔麻醉后暴露于 +2、+4 和 +6 Gz（每次 30 秒，上升速率 1G/s，每次间隔 15 分钟）。记录左心室收缩压（LVSP）、左心室压力上升峰值速率（+dp/dtmax）和心电图。结果显示，在 +2、+4 和 +6 Gz 暴露期间，LVSP 分别下降了 62.96%（P<0.01）、63.34%（P<0.01）和 82.01%（P<0.01），+dp/dtmax 分别下降了 58.46%（P<0.01）、53.59%（P<0.01）和 63.06%（P<0.01），左心室舒张末期压力与对照组相比分别下降了 67.78%（P>0.05）、332.74%（P<0.01）和 500.54%（P<0.01）。提示 +Gz 暴露会使心脏功能受到抑制。