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[高压氧对脑缺血损伤动物脑微循环及组织细胞的影响]

[Effect of hyperbaric oxygen on cerebral microcirculation and tissue cells in animals with cerebral ischemic injury].

作者信息

Lin S, Liu J, Xin P, Fang Y, Zhang Z, Zhou K

机构信息

Naval Medical Research Institute, Shanghai, China.

出版信息

Space Med Med Eng (Beijing). 1998 Oct;11(5):338-42.

PMID:11543255
Abstract

Changes of cerebral microcirculation and tissue cells after Hyperbaric Oxygen (HBO) exposure were observed in 136 gerbils with cerebral ischemia by observation of meningeal microcirculation pathological study in cerebral tissues and determination of Na, K-ATPase. It is indicated that HBO may be helpful in improving microcirculatory dynamics and other microcirculatory functions, and enhancing cerebral tissue cell activity and cell function, as well as increasing oxygen content. It is suggested that HBO (250 approximately 300kPa) may play a role in protecting vessel endothelial cells and nerve cells.

摘要

通过对136只脑缺血沙土鼠进行脑膜微循环观察、脑组织病理研究及钠钾ATP酶测定,观察了高压氧(HBO)暴露后脑微循环及组织细胞的变化。结果表明,HBO可能有助于改善微循环动力学及其他微循环功能,增强脑组织细胞活性和细胞功能,以及增加氧含量。提示HBO(250~300kPa)可能对血管内皮细胞和神经细胞起到保护作用。

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引用本文的文献

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Hyperbaric oxygen therapy in acute ischemic stroke: a review.急性缺血性卒中的高压氧治疗:综述
Interv Neurol. 2014 Aug;2(4):201-11. doi: 10.1159/000362677.
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Hyperbaric oxygenation alleviates MCAO-induced brain injury and reduces hydroxyl radical formation and glutamate release.高压氧治疗减轻 MCAO 诱导的脑损伤并减少羟自由基形成和谷氨酸释放。
Eur J Appl Physiol. 2010 Feb;108(3):513-22. doi: 10.1007/s00421-009-1229-9. Epub 2009 Oct 23.