单相抑郁症中多巴胺D(2)受体可用性及苯丙胺诱导的多巴胺释放

Dopamine D(2) receptor availability and amphetamine-induced dopamine release in unipolar depression.

作者信息

Parsey R V, Oquendo M A, Zea-Ponce Y, Rodenhiser J, Kegeles L S, Pratap M, Cooper T B, Van Heertum R, Mann J J, Laruelle M

机构信息

Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA.

出版信息

Biol Psychiatry. 2001 Sep 1;50(5):313-22. doi: 10.1016/s0006-3223(01)01089-7.

DOI:10.1016/s0006-3223(01)01089-7

PMID:11543733

Abstract

BACKGROUND

Reduced dopaminergic transmission has been implicated in the pathophysiology of major depression. The aim of the present study was to measure striatal D(2) receptor availability and amphetamine-induced dopamine release in nonpsychotic, unmedicated, unipolar patients during an episode of major depression.

METHODS

The striatal equilibrium specific to nonspecific partition coefficient (V(3)") of the D(2) receptor antagonist [(123)I]IBZM was measured with single photon emission computerized tomography before and after amphetamine administration in 9 depressed subjects and 10 matched healthy control subjects.

RESULTS

No significant differences were observed in preamphetamine D(2) receptor availability between depressed patients (0.73 +/- 0.08) and control subjects (0.78 +/- 0.10, p =.23). Amphetamine-induced reduction in [(123)I]IBZM V(3)" (DeltaV(3)") was similar in depressed patients (-9.8 +/- 5.5%) and control subjects (-7.8 +/- 2.5%, p =.32). Amphetamine induced a transient improvement in symptomatology in depressed patients, but this improvement did not correlate with [(123)I]IBZM DeltaV(3)".

CONCLUSIONS

This study did not replicate previously reported alterations in striatal D(2) receptor density in depressed patients and suggests that stimulant-induced dopamine release is not altered in major depression.

摘要

背景

多巴胺能传递减少与重度抑郁症的病理生理学有关。本研究的目的是测量非精神病性、未用药、单相抑郁症患者在重度抑郁发作期间纹状体D(2)受体可用性和苯丙胺诱导的多巴胺释放。

方法

在9名抑郁症患者和10名匹配的健康对照者中，在给予苯丙胺前后，用单光子发射计算机断层扫描测量D(2)受体拮抗剂[(123)I]IBZM的纹状体非特异性分配系数平衡比（V(3)")。

结果

抑郁症患者（0.73±0.08）和对照者（0.78±0.10，p = 0.23）在服用苯丙胺前的D(2)受体可用性无显著差异。苯丙胺诱导的[(123)I]IBZM V(3)"降低（DeltaV(3)")在抑郁症患者（-9.8±5.5%）和对照者（-7.8±2.5%，p = 0.32）中相似。苯丙胺使抑郁症患者的症状有短暂改善，但这种改善与[(123)I]IBZM DeltaV(3)"无关。