Sharma J B, Pundir P, Kumar A, Murthy N S
Department of Obstetrics and Gynecology, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India.
Int J Gynaecol Obstet. 2001 Sep;74(3):255-60. doi: 10.1016/s0020-7292(01)00448-9.
To compare the efficacy and safety of drotaverine hydrochloride and valethamate bromide in shortening the duration of labor.
In a randomized controlled trial of 150 nulliparous women in established labor with cervical dilation of 4 cm, 50 women were given drotaverine (group I), 50 women were given valethamate (group II) and another 50 women were not given any medication (group III). Duration of labor, mode of delivery, side effects, and neonatal outcome were measured in all cases. Appropriate non-parametric tests and chi(2) tests were used for assessment of statistical significance.
In the three groups, 100%, 96% and 46% women delivered within 6 h, respectively. The injection-to-delivery interval was significantly reduced in the drotaverine group (193.96 min) in contrast to the valethamate group (220.68 min) and control group (412.84 min). The rate of cervical dilation was highest in the drotaverine group (2.04 cm/h) compared with the valethamate bromide group (1.86 cm/h) and control group (1.01 cm/h). There were no major maternal or fetal adverse effects in any group, but minor side effects were more common in the valethamate group.
Both intramuscular drotaverine hydrochloride and valethamate bromide are effective in acceleration of labor; however, drotaverine accelerates labor more rapidly and is associated with less side effects.
比较盐酸屈他维林和溴戊胺太林在缩短产程方面的疗效和安全性。
在一项随机对照试验中，选取150名已进入产程、宫颈扩张4厘米的初产妇，50名妇女给予屈他维林（I组），50名妇女给予溴戊胺太林（II组），另外50名妇女未给予任何药物（III组）。测量所有病例的产程、分娩方式、副作用和新生儿结局。采用适当的非参数检验和卡方检验评估统计学意义。
三组中分别有100%、96%和46%的妇女在6小时内分娩。与溴戊胺太林组（220.68分钟）和对照组（412.84分钟）相比，屈他维林组的注射至分娩间隔显著缩短（193.96分钟）。屈他维林组的宫颈扩张率最高（2.04厘米/小时），高于溴戊胺太林组（1.86厘米/小时）和对照组（1.01厘米/小时）。任何一组均未出现严重母婴不良反应，但溴戊胺太林组的轻微副作用更为常见。
肌肉注射盐酸屈他维林和溴戊胺太林均能有效加速产程；然而，屈他维林加速产程的速度更快，且副作用更少。
