Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health, Education and Research Hospital, Ankara, Turkey.
Int J Gynaecol Obstet. 2009 Nov;107(2):126-9. doi: 10.1016/j.ijgo.2009.06.021. Epub 2009 Aug 6.
To compare the efficacy and safety of meperidine hydrochloride and valethamate bromide against placebo in shortening the duration of active labor.
We randomly assigned 160 nulliparous women with a singleton pregnancy at term who needed induction of labor to one of 3 treatments: 50 mg of meperidine (n=53), 16 mg of valethamate bromide (n=53), or a normal saline solution as placebo (n=54). All medications were given by slow intravenous infusion. Labor duration was the main outcome measure.
The intervals between infusion and complete cervical dilation and between infusion and delivery were significantly reduced (P<0.001 and P<0.01) in the meperidine group (103.0+/-64.5 minutes and 119.8+/-70.2 minutes), in contrast to the placebo group (173.9+/-74.8 minutes and 192.2+/-82.8 minutes). However, differences were not significant between the 2 treatment groups (139.6+/-63.1 minutes and 160.6+/-71.9 minutes), or between the valethamate bromide and the placebo group.
Meperidine, but not valethamate bromide, significantly shortened the duration of active labor in nulliparous women with a singleton pregnancy at term.
比较盐酸哌替啶和溴戊乙铵缩短活跃期的疗效和安全性。
我们将 160 例需要引产的初产妇分为三组，每组 53 例，分别接受 50mg 盐酸哌替啶、16mg 溴戊乙铵或生理盐水作为安慰剂的静脉缓慢滴注。主要观察指标为产程。
与安慰剂组（173.9+/-74.8 分钟和 192.2+/-82.8 分钟）相比，盐酸哌替啶组（103.0+/-64.5 分钟和 119.8+/-70.2 分钟）的输注到完全宫颈扩张和输注到分娩的间隔时间显著缩短（P<0.001 和 P<0.01）。但两组之间（139.6+/-63.1 分钟和 160.6+/-71.9 分钟）或溴戊乙铵组与安慰剂组之间无显著差异。
盐酸哌替啶而非溴戊乙铵显著缩短了足月初产妇活跃期的产程。
