Akalin E, Murphy B
Renal Division, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1243, New York, NY 10029, USA.
Curr Opin Immunol. 2001 Oct;13(5):572-6. doi: 10.1016/s0952-7915(00)00261-2.
The influence of gene polymorphisms in key immunoregulatory molecules on the clinical course post-transplant has become an area of active research, since it offers a possible explanation for the heterogeneity in outcomes between individuals. Several groups have now investigated the association of polymorphisms in molecules--including cytokines, cytokine receptors, adhesion molecules and costimulatory molecules--that participate in the immune response to an allograft. Several interesting observations have been made that would suggest that genetic variability influencing allograft survival reaches beyond that of the MHC molecules.
关键免疫调节分子中的基因多态性对移植后临床病程的影响已成为一个活跃的研究领域，因为它为个体间结果的异质性提供了一种可能的解释。目前有几个研究小组调查了参与同种异体移植免疫反应的分子（包括细胞因子、细胞因子受体、黏附分子和共刺激分子）中的多态性之间的关联。已经有一些有趣的观察结果表明，影响同种异体移植存活的基因变异性超出了MHC分子的范围。
