白细胞介素2-白细胞介素21基因簇多态性与肾移植后的移植肾功能无关。
IL2-IL21 gene cluster polymorphism is not associated with allograft function after kidney transplantation.
作者信息
Kwiatkowska Ewa, Domanski Leszek, Kłoda Karolina, Pawlik Andrzej, Safranow Krzysztof, Ciechanowski Kazimierz
机构信息
Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
出版信息
Int Urol Nephrol. 2014 Dec;46(12):2415-20. doi: 10.1007/s11255-014-0867-y. Epub 2014 Nov 8.
BACKGROUND
Cytokines are key mediators of the immune response after transplantation. The interleukin (IL)-2 cytokine family, which includes IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, is of particular interest because of its importance in the allogenic response. The aim of this study was to examine the association between the rs6822844 gene polymorphism in the IL2-IL21 region and allograft function after kidney transplantation.
METHODS
The study enrolled 270 Caucasian kidney allograft recipients (166 males and 104 females, mean age 47.63 ± 12.96 years). Following parameters were recorded in each case: recipient's age, delayed graft function (DGF), occurrence and number of episodes of acute rejection (AR), and chronic allograft dysfunction (CAD). Genotyping of the rs6822844 IL2-IL21 cluster gene polymorphism was performed using real-time PCR assay.
RESULTS
There were no statistically significant differences in the genotypes and alleles of the rs6822844 IL2-IL21 cluster gene polymorphism among patients with DGF (p = 0.72), AR (p = 0.69) and CAD (p = 0.77), or in creatinine concentrations 1, 3, 6, 12, 24 or 36 months after transplantation (p = 0.46, p = 0.58, p = 0.6, p = 0.72, p = 0.7, p = 0.76, respectively).
CONCLUSION
It seems that the rs6822844 IL2-IL21 gene cluster polymorphism is of little importance in allograft function after kidney transplantation.
背景
细胞因子是移植后免疫反应的关键介质。白细胞介素（IL）-2细胞因子家族，包括IL-2、IL-4、IL-7、IL-9、IL-15和IL-21，因其在同种异体反应中的重要性而备受关注。本研究的目的是探讨IL2-IL21区域的rs6822844基因多态性与肾移植后同种异体移植物功能之间的关联。
方法
本研究纳入了270名白种人肾移植受者（166名男性和104名女性，平均年龄47.63±12.96岁）。记录每个病例的以下参数：受者年龄、移植肾功能延迟恢复（DGF）、急性排斥反应（AR）发作的发生情况和次数，以及慢性移植物功能障碍（CAD）。使用实时PCR检测法对rs6822844 IL2-IL21基因簇基因多态性进行基因分型。
结果
DGF患者（p = 0.72）、AR患者（p = 0.69）和CAD患者（p = 0.77）中，rs6822844 IL2-IL21基因簇基因多态性的基因型和等位基因，或移植后1、3、6、12、24或36个月时的肌酐浓度，均无统计学显著差异（分别为p = 0.46、p = 0.58、p = 0.6、p = 0.72、p = 0.7、p = 0.76）。
结论
rs6822844 IL2-IL21基因簇多态性似乎在肾移植后同种异体移植物功能中作用不大。
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