p120连环蛋白对Rho GTP酶的调控

Regulation of Rho GTPases by p120-catenin.

作者信息

Anastasiadis P Z, Reynolds A B

机构信息

Department of Cancer Biology, Vanderbilt University, 1161 21st Ave South, MCN C-2310, Nashville, Tennessee 37232, USA.

出版信息

Curr Opin Cell Biol. 2001 Oct;13(5):604-10. doi: 10.1016/s0955-0674(00)00258-1.

DOI:10.1016/s0955-0674(00)00258-1

PMID:11544030

Abstract

Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism of action and provide a potential explanation for the metastatic phenotype exhibited in carcinoma cells that have lost E cadherin expression.

摘要

最近的三项报告表明，p120连环蛋白可以调节RhoA、Rac和Cdc42的活性，这提示了一种调控黏附性和运动性细胞表型之间平衡的精妙且前所未有的机制。这些报告中的观察结果为p120的作用机制提供了重要的新线索，并为在失去E钙黏蛋白表达的癌细胞中表现出的转移表型提供了一种潜在解释。