N-钙黏蛋白拮抗剂和激动剂的潜在治疗应用
Potential Therapeutic Applications of N-Cadherin Antagonists and Agonists.
作者信息
Blaschuk Orest W
机构信息
Zonula Incorporated, Kirkland, QC, Canada.
出版信息
Front Cell Dev Biol. 2022 Mar 3;10:866200. doi: 10.3389/fcell.2022.866200. eCollection 2022.
Abstract
This review focuses on the cell adhesion molecule (CAM), known as neural (N)-cadherin (CDH2). The molecular basis of N-cadherin-mediated intercellular adhesion is discussed, as well as the intracellular signaling pathways regulated by this CAM. N-cadherin antagonists and agonists are then described, and several potential therapeutic applications of these intercellular adhesion modulators are considered. The usefulness of N-cadherin antagonists in treating fibrotic diseases and cancer, as well as manipulating vascular function are emphasized. Biomaterials incorporating N-cadherin modulators for tissue regeneration are also presented. N-cadherin antagonists and agonists have potential for broad utility in the treatment of numerous maladies.
摘要
本综述聚焦于一种名为神经（N）-钙黏蛋白（CDH2）的细胞黏附分子。文中讨论了N-钙黏蛋白介导的细胞间黏附的分子基础，以及受该细胞黏附分子调控的细胞内信号通路。接着描述了N-钙黏蛋白拮抗剂和激动剂，并探讨了这些细胞间黏附调节剂的几种潜在治疗应用。重点强调了N-钙黏蛋白拮抗剂在治疗纤维化疾病和癌症以及调节血管功能方面的作用。还介绍了用于组织再生的含有N-钙黏蛋白调节剂的生物材料。N-钙黏蛋白拮抗剂和激动剂在治疗多种疾病方面具有广泛的应用潜力。
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