激活素-卵泡抑素系统在肾脏发育和再生过程中的作用。
The role of the activin-follistatin system in the developmental and regeneration processes of the kidney.
作者信息
Maeshima A, Nojima Y, Kojima I
机构信息
Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371-8512, Japan.
出版信息
Cytokine Growth Factor Rev. 2001 Dec;12(4):289-98. doi: 10.1016/s1359-6101(01)00010-7.
Regeneration processes in many tissues are modulated by various factors, which are involved in their organogenesis. Activin A, a member of the TGF-beta superfamily, inhibits branching tubulogenesis of the kidney in organ culture system as well as in in vitro tubulogenesis model. On the other hand, follistatin, an antagonist activin A, reverses the effect of activin A on kidney development, induces branching tubulogenesis, and also promotes tubular regeneration after ischemia/reperfusion injury by blocking the action of endogenous activin A. The activin-follistatin system is one of the important regulatory systems modulating developmental and regeneration processes of the kidneys.
许多组织中的再生过程受到多种因素的调节，这些因素参与了它们的器官发生。激活素A是转化生长因子-β超家族的成员之一，在器官培养系统以及体外肾小管生成模型中均抑制肾脏的分支肾小管生成。另一方面，卵泡抑素作为激活素A的拮抗剂，可逆转激活素A对肾脏发育的影响，诱导分支肾小管生成，并且通过阻断内源性激活素A的作用促进缺血/再灌注损伤后的肾小管再生。激活素-卵泡抑素系统是调节肾脏发育和再生过程的重要调节系统之一。
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