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本文引用的文献

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Biofilm formation as microbial development.生物膜形成作为微生物发育过程。
Annu Rev Microbiol. 2000;54:49-79. doi: 10.1146/annurev.micro.54.1.49.
2
Genetic analysis of sliding motility in Mycobacterium smegmatis.耻垢分枝杆菌滑动运动的遗传分析。
J Bacteriol. 2000 Aug;182(15):4348-51. doi: 10.1128/JB.182.15.4348-4351.2000.
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A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.结核分枝杆菌的索状形成、持续性和毒力需要一种新型分枝菌酸环丙烷合成酶。
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Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice.复合脂质决定了结核分枝杆菌在小鼠体内的组织特异性复制。
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Sliding motility in mycobacteria.分枝杆菌中的滑动运动性。
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Steps in the development of a Vibrio cholerae El Tor biofilm.霍乱弧菌埃尔托生物膜形成的步骤。
Mol Microbiol. 1999 Nov;34(3):586-95. doi: 10.1046/j.1365-2958.1999.01624.x.
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Genetic approaches to study of biofilms.研究生物膜的遗传学方法。
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9
Identification of a peptide synthetase involved in the biosynthesis of glycopeptidolipids of Mycobacterium smegmatis.
Mol Microbiol. 1999 Sep;33(6):1244-53. doi: 10.1046/j.1365-2958.1999.01572.x.
10
Change in colony morphology influences the virulence as well as the biochemical properties of the Mycobacterium avium complex.鸟分枝杆菌复合体的菌落形态变化会影响其毒力以及生化特性。
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糖肽脂乙酰化影响耻垢分枝杆菌的滑动运动性和生物膜形成。

Glycopeptidolipid acetylation affects sliding motility and biofilm formation in Mycobacterium smegmatis.

作者信息

Recht J, Kolter R

机构信息

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

J Bacteriol. 2001 Oct;183(19):5718-24. doi: 10.1128/JB.183.19.5718-5724.2001.

DOI:10.1128/JB.183.19.5718-5724.2001
PMID:11544235
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC95464/
Abstract

The absence of glycopeptidolipids (GPLs) abolishes the ability of mycobacteria both to slide over the surface of motility plates and to form biofilms on polyvinyl chloride. In a screen for biofilm-defective mutants of Mycobacterium smegmatis mc(2)155, a new mutant was obtained that resulted in partial inhibition of both processes and also showed an intermediate rough colony morphology. The mariner transposon insertion mapped to a GPL biosynthesis gene (atf1) which encodes a putative acetyltranferase involved in the transfer of acetyl groups to the glycopeptide core. Physical characterization of the GPLs from the atf1 mutant demonstrated that they were not acetylated.

摘要

糖脂（GPLs）的缺失消除了分枝杆菌在运动平板表面滑动以及在聚氯乙烯上形成生物膜的能力。在耻垢分枝杆菌mc(2)155生物膜缺陷突变体的筛选中，获得了一个新的突变体，该突变体导致这两个过程均受到部分抑制，并且还表现出中间粗糙的菌落形态。水手转座子插入定位到一个GPL生物合成基因（atf1），该基因编码一种假定的乙酰转移酶，参与将乙酰基转移到糖肽核心。来自atf1突变体的GPLs的物理特性表明它们没有被乙酰化。