The experimental use of antisense oligonucleotides: a guide for the perplexed.
作者信息
Stein C A
机构信息
Columbia University, 630 West 168 Street, New York, New York 10032, USA.
出版信息
J Clin Invest. 2001 Sep;108(5):641-4. doi: 10.1172/JCI13885.
Abstract
摘要
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本文引用的文献
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Bcl-xL in prostate cancer cells: effects of overexpression and down-regulation on chemosensitivity.前列腺癌细胞中的Bcl-xL：过表达和下调对化学敏感性的影响
Cancer Res. 2000 Nov 1;60(21):6052-60.
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Tetranucleotide GGGA motif in primary RNA transcripts. Novel target site for antisense design.初级RNA转录本中的四核苷酸GGGA基序。反义设计的新靶点。
J Biol Chem. 1998 Sep 25;273(39):25125-31. doi: 10.1074/jbc.273.39.25125.
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Formation of a G-tetrad and higher order structures correlates with biological activity of the RelA (NF-kappaB p65) 'antisense' oligodeoxynucleotide.G-四联体及更高阶结构的形成与RelA（核因子κB p65）“反义”寡脱氧核苷酸的生物学活性相关。
Nucleic Acids Res. 1997 Jul 1;25(13):2648-56. doi: 10.1093/nar/25.13.2648.
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Cell-surface perturbations of the epidermal growth factor and vascular endothelial growth factor receptors by phosphorothioate oligodeoxynucleotides.硫代磷酸酯寡脱氧核苷酸对表皮生长因子和血管内皮生长因子受体的细胞表面扰动
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6523-8. doi: 10.1073/pnas.94.12.6523.
6
Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein.巨噬细胞-1抗原（CD11b/CD18）是一种寡脱氧核苷酸结合蛋白。
Nat Med. 1997 Apr;3(4):414-20. doi: 10.1038/nm0497-414.
7
Polydeoxyguanine motifs in a 12-mer phosphorothioate oligodeoxynucleotide augment binding to the v3 loop of HIV-1 gp120 and potency of HIV-1 inhibition independency of G-tetrad formation.12聚体硫代磷酸酯寡脱氧核苷酸中的聚脱氧鸟嘌呤基序增强了与HIV-1 gp120的v3环的结合以及HIV-1抑制效力，与G-四联体的形成无关。
Antisense Nucleic Acid Drug Dev. 1996 Winter;6(4):281-9. doi: 10.1089/oli.1.1996.6.281.
8
Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.寡脱氧核苷酸和细菌DNA中的CpG基序对小鼠和人类细胞中NK活性的诱导作用。
J Immunol. 1996 Sep 1;157(5):1840-5.
9
Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase.一种靶向C-raf激酶的硫代磷酸反义寡脱氧核苷酸的抗肿瘤活性。
Nat Med. 1996 Jun;2(6):668-75. doi: 10.1038/nm0696-668.
10
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.细菌DNA中存在的CpG基序可迅速诱导淋巴细胞分泌白细胞介素6、白细胞介素12和干扰素γ。
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2879-83. doi: 10.1073/pnas.93.7.2879.
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