Kornel L, Miyabo S
Steroids. 1975 Jun;25(6):697-706. doi: 10.1016/0039-128x(75)90034-3.
Following i.v. administration of [4-14C]cortisol, various sulfate conjugated metabolites of cortisol in urine were identified and their respective excretion rates measured. The results obtained demonstrated the following: 1) sulfate conjugates as a group are excreted considerably slower than glucuronide conjugates; 2) sulfate conjugates of steroids with non-reduced ring-A (C-21 sulfates) are excreted (and presumably formed) much faster than steroid-3-sulfates, which require reduction of the ring-A prior to the conjugation; 3) the excretion of C-3 sulfates of ring-A reduced steroids with glycerol side-chain (cortols and cortolones) is significantly faster than those of the corresponding steroids with dihydroxyacetone side-chain (THF, THE and their 5alpha-isomers); 4) the relative concentrations of C-21 sulfates of steroids with ring-A intact (FK, EK, ER, epiER and 6beta-hydroxycortisol) are much higher than the concentrations of C-21 glucuronides of these steroids.
静脉注射[4-¹⁴C]皮质醇后，对尿液中皮质醇的各种硫酸酯共轭代谢物进行了鉴定，并测量了它们各自的排泄率。所得结果表明：1）硫酸酯共轭物作为一个整体，其排泄速度比葡萄糖醛酸酯共轭物慢得多；2）具有未还原A环的类固醇的硫酸酯共轭物（C-21硫酸盐）的排泄（可能也是形成）速度比类固醇-3-硫酸盐快得多，后者在共轭之前需要A环还原；3）具有甘油侧链的A环还原类固醇（皮质醇和皮质酮）的C-3硫酸盐的排泄速度明显快于具有二羟基丙酮侧链的相应类固醇（四氢皮质醇、四氢皮质酮及其5α-异构体）；4）具有完整A环的类固醇（FK、EK、ER、表ER和6β-羟基皮质醇）的C-21硫酸盐的相对浓度远高于这些类固醇的C-21葡萄糖醛酸酯的浓度。
