Fehér G K, Fehér T, Zahumenszky Z
Endokrinologie. 1979 Apr;73(2):167-72.
Unconjugated, sulpho- and glucurono-conjugated androgen hormone metabolites have been determined in the urine of patients with rheumatoid arthritis. An increase in the excretory rate of unconjugated 5 beta-reduced 17-ketosteroids and a decrease in that of 17-ketosteroid conjugates, especially in dehydroepiandrosterone sulphate and in the sum of dehydroepiandrosterone, etiocholanolone and androsterone glucuronoside were observed. In contrast to unconjugated metabolites, there was less significant change in the 5 beta-metabolite conjugates in urine. Corticosteroid treatment resulted in an additional decrease of metabolite excretion by patients. Further study is necessary to determine the causative factors in the altered steroid pattern observed in this severe, non-endocrine disease.
已对类风湿性关节炎患者尿液中的未结合型、硫酸化和葡糖醛酸化雄激素激素代谢物进行了测定。观察到未结合的5β-还原17-酮类固醇排泄率增加，而17-酮类固醇结合物排泄率降低，尤其是硫酸脱氢表雄酮以及脱氢表雄酮、本胆烷醇酮和雄甾酮葡糖苷的总和。与未结合的代谢物相比，尿液中5β-代谢物结合物的变化不太显著。皮质类固醇治疗导致患者代谢物排泄进一步减少。有必要进行进一步研究，以确定在这种严重的非内分泌疾病中观察到的类固醇模式改变的致病因素。
