Bansal B C, Gupta R R, Bansal M R, Prakash C
Stroke. 1975 May-Jun;6(3):304-7. doi: 10.1161/01.str.6.3.304.
Serum lipids and serum uric acid have been studied in 50 patients with ischemic thrombotic cerebrovascular disease. Patients having diseases known to predispose to hyperuricemia were excluded. Abnormalities of large vessels were present in 14 or 30 cases (46.6%) as a whole, and in 9 of 16 cases (56.5%) below 40 years of age. Thirty percent of the cases showed hyperuricemia. A statistically significant rise in serum triglycerides, pre-beta lipoproteins and serum uric acid was found in all 50 patients and in patients below 40 years of age. In patients above 40 years of age, only the rise in serum triglycerides and pre-beta lipoproteins was found to be statistically significant. A statistically significant rise in serum triglycerides, pre-beta lipoproteins, cholesterols and uric acid was found in patients with abnormal angiograms. A statistically significant correlation was observed between serum uric acid and serum triglycerides in all the groups, between serum uric acid and pre-beta lipoprotein in patients below 40 years of age, and between serum uric acid and serum phospholipids in patients with abnormal angiograms. These factors may be playing a role in the causation of ischemic thrombotic cerebrovascular disease in general and especially in patients below 40 years of age.
对50例缺血性血栓性脑血管病患者的血脂和血清尿酸进行了研究。排除已知易患高尿酸血症的疾病患者。总体上，14例（46.6%）或30例患者存在大血管异常，40岁以下的16例患者中有9例（56.5%）存在大血管异常。30%的病例表现为高尿酸血症。在所有50例患者以及40岁以下的患者中，血清甘油三酯、前β脂蛋白和血清尿酸均有统计学意义的升高。在40岁以上的患者中，仅发现血清甘油三酯和前β脂蛋白的升高具有统计学意义。血管造影异常的患者血清甘油三酯、前β脂蛋白、胆固醇和尿酸有统计学意义的升高。在所有组中，血清尿酸与血清甘油三酯之间、40岁以下患者血清尿酸与前β脂蛋白之间以及血管造影异常患者血清尿酸与血清磷脂之间均观察到统计学意义的相关性。这些因素可能在一般缺血性血栓性脑血管病的病因中起作用，尤其是在40岁以下的患者中。
