Toussaint J F, Pachot-Clouard M, Kantor H L
Service de Physiologie, Hôpital Européen Georges Pompidou, Paris, France.
J Cardiovasc Magn Reson. 2000;2(3):225-32. doi: 10.3109/10976640009146572.
Developing imaging technologies capable of identifying unstable atheromatous plaques in vivo is a major issue of clinical cardiovascular research. These techniques would permit an earlier surgical or medical therapy and would anticipate acute ischemic syndromes. Plaque vulnerability depends on the relative amount and thickness of its lipid core and fibrous cap. Several means of assessing atherosclerotic plaque composition have been used with nuclear magnetic resonance (NMR): carbon-13 and proton spectroscopy, proton imaging, chemical shift imaging, water diffusion imaging, and magnetization transfer. Recent data have shown that MR allows for accurate in vivo diagnosis and may support large scale prevention studies.
开发能够在体内识别不稳定动脉粥样硬化斑块的成像技术是临床心血管研究的一个主要问题。这些技术将允许早期进行手术或药物治疗，并能预测急性缺血综合征。斑块易损性取决于其脂质核心和纤维帽的相对数量和厚度。已经使用了几种通过核磁共振（NMR）评估动脉粥样硬化斑块成分的方法：碳-13和质子光谱、质子成像、化学位移成像、水扩散成像和磁化传递。最近的数据表明，磁共振成像能够进行准确的体内诊断，并可能支持大规模预防研究。
