Toussaint J F
Massachusetts General Hospital, Harvard Medical School, Et Service de Cardiologie, Hôpital Cochin, Paris.
Ann Radiol (Paris). 1995;38(1-2):91-7.
Diagnosis and prognosis of atherosclerosis can no longer be evaluated with morphological parameters only. A description of atherosclerotic plaque composition is necessary to study the mechanisms of plaque rupture, which depends on collagenous cap and lipid core thicknesses. NMR, as a biochemical imaging technique, allows visualization of these components using T1 contrast (mobile lipids), T2 contrast (cap vs. core), spin density (calcifications), diffusion imaging, 1H and 13C spectroscopy. Today, these imaging sequences allow to study in vitro the effects of interventional techniques such as angioplasty or atherectomy. Clinical investigations begin, which will attempt to develop in vivo microscopy and test the ability of NMR to predict plaque rupture.
动脉粥样硬化的诊断和预后评估不能再仅依靠形态学参数。描述动脉粥样硬化斑块的组成对于研究斑块破裂机制很有必要，而斑块破裂取决于胶原帽和脂质核心的厚度。核磁共振成像（NMR）作为一种生化成像技术，能够利用T1对比度（流动脂质）、T2对比度（帽与核心）、自旋密度（钙化）、扩散成像、1H和13C光谱对这些成分进行可视化。如今，这些成像序列可用于体外研究血管成形术或斑块旋切术等介入技术的效果。临床研究已经启动，旨在开发体内显微镜技术并测试核磁共振成像预测斑块破裂的能力。
