Guay A T, Perez J B, Jacobson J, Newton R A
Department of Endocrinology, Lahey Clinic, Peabody, Massachusetts 01960, USA.
J Androl. 2001 Sep-Oct;22(5):793-7.
The objective of this study was to determine the efficacy and safety of sildenafil in patients with erectile dysfunction (ED) and associated organic risk factors in a multispecialty clinic. Patients (n = 521) were diagnosed with ED based on self-assessment. Associated risk factors were managed by medication or life-style modifications, or both, before treatment with sildenafil for ED. Patients received a 50-mg dose of sildenafil that could be adjusted to 100 mg or 25 mg based on tolerability and efficacy. Patients recorded the number of successful intercourse encounters for 6 to 8 weeks, and the number of adverse events. Overall, there was an 82% successful intercourse rate with sildenafil treatment. The predominant associated risk factors for ED were hypertension (39%), hypogonadism (37%), and multiple medications (34%). Common adverse events due to sildenafil treatment were mild to moderate in nature and resulted in <2% patient discontinuation. Clinicians should be particularly careful to evaluate patients presenting with ED because the condition can be accompanied by a wide spectrum of risk factors requiring monitoring and treatment. However, with adequate treatment and control of these risk factors, the use of sildenafil in a representative population of men with ED in a multispecialty clinic can achieve a higher efficacy rate than previous studies have indicated.
本研究的目的是在一家多专科诊所中，确定西地那非对患有勃起功能障碍（ED）及相关器质性风险因素的患者的疗效和安全性。患者（n = 521）基于自我评估被诊断为ED。在使用西地那非治疗ED之前，通过药物治疗或生活方式改变或两者兼用，对相关风险因素进行管理。患者接受50毫克剂量的西地那非治疗，可根据耐受性和疗效调整至100毫克或25毫克。患者记录6至8周内成功性交的次数以及不良事件的数量。总体而言，西地那非治疗的性交成功率为82%。ED的主要相关风险因素为高血压（39%）、性腺功能减退（37%）和多种药物治疗（34%）。西地那非治疗引起的常见不良事件性质为轻至中度，导致停药的患者不到2%。临床医生应特别谨慎地评估出现ED的患者，因为该病症可能伴有多种需要监测和治疗的风险因素。然而，通过对这些风险因素进行充分治疗和控制，在一家多专科诊所中，对有代表性的ED男性人群使用西地那非可取得比以往研究表明的更高的有效率。
