Palmer H E, Rieksts G A, Palmer R F, Gillis M F
Aviat Space Environ Med. 1979 Aug;50(8):768-73.
Sodium-22 has been studied as a tracer for bone mineral metabolism in rats and dogs. When incorporated into bone during growth from birth to adulthood, the bone becomes uniformly tagged with 22Na, which is released through the metabolic turnover of the bone. The 22Na not incorporated in the bone matrix is rapidly excreted within a few days when animals are fed high, but nontoxic levels of NaCl. The 22Na tracer can be used to measure bone mineral loss in animals during space flight and in research on bone disease.
钠-22已被作为大鼠和狗骨矿物质代谢的示踪剂进行研究。从出生到成年生长过程中，当它被整合到骨骼中时，骨骼会被22Na均匀标记，而22Na会通过骨骼的代谢转换而释放。当给动物喂食高但无毒水平的氯化钠时，未整合到骨基质中的22Na会在几天内迅速排出。22Na示踪剂可用于测量动物在太空飞行期间的骨矿物质流失以及用于骨疾病研究。
