Li J B, Yu Y S, Ma Y L, Zhou W L, Yu X Z
Dept. of Infectious Diseases, First Affiliated Hospital, College of Medical Science, Zhejiang University, China.
Infection. 2001 Aug;29(4):228-31. doi: 10.1007/s15010-001-1186-7.
This study analyzes the prevalence of hospital and community-acquired infections caused by Escherichia coli.
The antibiotic resistance pattern was used to characterize the isolates, and a retrospective observational study was performed to assess the relationship between antimicrobial use and bacterial resistance. The study was conducted during a 1-year and 7-month period in a 1,500-bed tertiary care hospital in Anhui, China.
An E. coli infection was diagnosed in 1.4% of patients (519/36,179) admitted to the hospital between March 1, 1999 and August 31, 2000. Of the 519 isolates, 489 (94.2%) were resistant to at least one antimicrobial; 86% were resistant to ampicillin, 85% to cephalothin, 83% to piperacillin, 77% to ampicillin/sulbactam, 72% to trimethoprim/sulfamethoxazole (TMP-SMZ), 70% to ciprofloxacin, 61% to cefoperazone, 58% to tobramycin, 56% to gentamicin, 48% to ticarcillin-clavulanate, 44% to cefazolin, 43% to cefuroxime, 36% to cefoxitin, 32% to cefepime, 29% to aztreonam, cefetaxime and ceftriaxone, 28% to ceftazidime, 19% to piperacillin/tazobactam, 10% to amikacin, while all strains tested were susceptible to imipenem.
Prior receipt of amtimicrobial therapy was significantly associated with infection caused by a resistant organism.
本研究分析了由大肠杆菌引起的医院感染和社区获得性感染的患病率。
采用抗生素耐药模式对分离株进行特征分析，并进行回顾性观察研究以评估抗菌药物使用与细菌耐药性之间的关系。该研究在位于中国安徽的一家拥有1500张床位的三级医院进行，为期1年零7个月。
在1999年3月1日至2000年8月31日期间入院的患者中，1.4%（519/36179）被诊断为大肠杆菌感染。在这519株分离株中，489株（94.2%）对至少一种抗菌药物耐药；86%对氨苄西林耐药，85%对头孢噻吩耐药，83%对哌拉西林耐药，77%对氨苄西林/舒巴坦耐药，72%对甲氧苄啶/磺胺甲恶唑（TMP-SMZ）耐药，70%对环丙沙星耐药，61%对头孢哌酮耐药，58%对妥布霉素耐药，56%对庆大霉素耐药，48%对替卡西林-克拉维酸耐药，44%对头孢唑林耐药，43%对头孢呋辛耐药，36%对头孢西丁耐药，32%对头孢吡肟耐药，29%对氨曲南、头孢噻肟和头孢曲松耐药，28%对头孢他啶耐药，19%对哌拉西林/他唑巴坦耐药，10%对阿米卡星耐药，而所有测试菌株对亚胺培南敏感。
先前接受抗菌治疗与耐药菌引起的感染显著相关。
