用于癌症治疗的树突状细胞疫苗。

Dendritic cell vaccines for cancer therapy.

作者信息

Sprinzl G M, Kacani L, Schrott-Fischer A, Romani N, Thumfart W F

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, University of Innsbruck, Austria.

出版信息

Cancer Treat Rev. 2001 Aug;27(4):247-55. doi: 10.1053/ctrv.2001.0221.

DOI:10.1053/ctrv.2001.0221

PMID:11545544

Abstract

Dendritic cells (DC) are professional antigen-presenting cells whose primary function is the initiation of immune response. Based on the finding that the immune system usually fails to identify and kill cancer cells, DC have been recently used as vaccines for stimulation of tumour-specific immunity. This review focuses on pitfalls related to DC-based vaccination against solid tumours and on improvement of this immunotherapeutic approach for routine treatment of cancer disease.

摘要

树突状细胞（DC）是专职抗原呈递细胞，其主要功能是启动免疫反应。基于免疫系统通常无法识别和杀死癌细胞这一发现，树突状细胞最近已被用作刺激肿瘤特异性免疫的疫苗。本综述重点关注基于树突状细胞的实体瘤疫苗接种相关的陷阱，以及改进这种免疫治疗方法以用于癌症疾病的常规治疗。