大鼠肝细胞游离体系对肝癌致癌物3'-甲基-4-二甲基氨基偶氮苯的代谢激活。有证据表明至少形成了两种亲电代谢产物。 - Suppr | 超能文献

Metabolic activation of the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene by a rat liver cell-free system. Evidence suggesting the formation of at least two electrophilic metabolites.

作者信息

Labuc G E, Blunck J M

出版信息

Biochem Pharmacol. 1979 Aug 1;28(15):2367-73. doi: 10.1016/0006-2952(79)90702-0.

DOI:10.1016/0006-2952(79)90702-0

Abstract

摘要

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Metabolic activation of the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene by a rat liver cell-free system. Evidence suggesting the formation of at least two electrophilic metabolites.大鼠肝细胞游离体系对肝癌致癌物3'-甲基-4-二甲基氨基偶氮苯的代谢激活。有证据表明至少形成了两种亲电代谢产物。

Biochem Pharmacol. 1979 Aug 1;28(15):2367-73. doi: 10.1016/0006-2952(79)90702-0.

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Inhibition of chemical carcinogenesis: early increase in tissue uptake and macromolecular binding of [3H]-labelled metabolites of the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene in rat liver in vivo in the presence of the tumour inhibitor chloramphenicol.化学致癌作用的抑制：在肿瘤抑制剂氯霉素存在的情况下，大鼠肝脏中[3H]标记的肝癌致癌物3'-甲基-4-二甲基氨基偶氮苯代谢物的组织摄取和大分子结合在体内早期增加。

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In vitro incorporation of 3'-methyl-4-dimethylaminoazobenzene into liver nuclei and release of RNA from the nuclei.3'-甲基-4-二甲基氨基偶氮苯在体外掺入肝细胞核及RNA从细胞核中的释放。

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Participation of the microsomal electron transport system in mutagenic activation of 4-dimethylaminoazobenzene, 4-methylaminoazobenzene and their 3'-methyl-derivatives.微粒体电子传递系统参与4-二甲基氨基偶氮苯、4-甲基氨基偶氮苯及其3'-甲基衍生物的诱变激活作用。

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Inhibition by 3'-methyl-4-dimethylamino-azobenzene of in vitro cell-free protein synthesis: possible involvement of an electrophilic metabolite.3'-甲基-4-二甲基氨基偶氮苯对体外无细胞蛋白质合成的抑制作用：亲电代谢物可能的参与。

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Localization of minor liver-bound metabolites of 3-methyl-p-dimethylaminoazobenzene with anti-hapten antibodies.用抗半抗原抗体对3-甲基-对二甲氨基偶氮苯的肝脏结合性次要代谢产物进行定位

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Inhibition of 3'-methyl-4-dimethylaminoazobenzene (3'MeDAB)-induced hepatocarcinogenesis in the rat: chloramphenicol inhibits N,N-dimethylaniline N-oxidase and in vitro binding of [3H]3'MeDAB to protein but not to RNA.抑制大鼠中3'-甲基-4-二甲基氨基偶氮苯（3'MeDAB）诱导的肝癌发生：氯霉素抑制N，N-二甲基苯胺N-氧化酶以及[3H]3'MeDAB与蛋白质而非RNA的体外结合。

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Binding of 3'-methyl-4-dimethylaminoazobenzene to nuclear ribonucleoprotein particles.3'-甲基-4-二甲基氨基偶氮苯与核糖核蛋白颗粒的结合。

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Effects of 3'-methyl-4-dimethylaminoazobenzene on RNA processing in rat liver nuclei.3'-甲基-4-二甲基氨基偶氮苯对大鼠肝细胞核中RNA加工的影响。

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Detection by antihapten antibodies of liver-bound compounds related to azocarcinogens or their metabolites.通过抗半抗原抗体检测与偶氮致癌物或其代谢产物相关的肝结合化合物。

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