Inhibition of chemical carcinogenesis: early increase in tissue uptake and macromolecular binding of [3H]-labelled metabolites of the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene in rat liver in vivo in the presence of the tumour inhibitor chloramphenicol.
作者信息
Labuc G E, Blunck J M
出版信息
Biochem Pharmacol. 1980 Aug 15;29(16):2252-5. doi: 10.1016/0006-2952(80)90207-5.
PMID:6775635
Abstract
摘要
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1
Inhibition of chemical carcinogenesis: early increase in tissue uptake and macromolecular binding of [3H]-labelled metabolites of the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene in rat liver in vivo in the presence of the tumour inhibitor chloramphenicol.化学致癌作用的抑制：在肿瘤抑制剂氯霉素存在的情况下，大鼠肝脏中[3H]标记的肝癌致癌物3'-甲基-4-二甲基氨基偶氮苯代谢物的组织摄取和大分子结合在体内早期增加。
Biochem Pharmacol. 1980 Aug 15;29(16):2252-5. doi: 10.1016/0006-2952(80)90207-5.
2
Inhibition of 3'-methyl-4-dimethylaminoazobenzene (3'MeDAB)-induced hepatocarcinogenesis in the rat: chloramphenicol inhibits N,N-dimethylaniline N-oxidase and in vitro binding of [3H]3'MeDAB to protein but not to RNA.抑制大鼠中3'-甲基-4-二甲基氨基偶氮苯（3'MeDAB）诱导的肝癌发生：氯霉素抑制N，N-二甲基苯胺N-氧化酶以及[3H]3'MeDAB与蛋白质而非RNA的体外结合。
Biochem Pharmacol. 1979 Oct 1;28(19):3032-4. doi: 10.1016/0006-2952(79)90608-7.
3
Metabolic activation of the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene by a rat liver cell-free system. Evidence suggesting the formation of at least two electrophilic metabolites.大鼠肝细胞游离体系对肝癌致癌物3'-甲基-4-二甲基氨基偶氮苯的代谢激活。有证据表明至少形成了两种亲电代谢产物。
Biochem Pharmacol. 1979 Aug 1;28(15):2367-73. doi: 10.1016/0006-2952(79)90702-0.
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Localization of minor liver-bound metabolites of 3-methyl-p-dimethylaminoazobenzene with anti-hapten antibodies.用抗半抗原抗体对3-甲基-对二甲氨基偶氮苯的肝脏结合性次要代谢产物进行定位
Cancer Res. 1977 Jul;37(7 Pt 1):2099-104.
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Modifications of 3'-methyl-4-dimethylaminoazobenzene carcinogenesis of rat liver and carcinogen metabolism by portacaval anastomosis.
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The effect of propranolol on induction of rat liver tumors by a chemical carcinogen.普萘洛尔对化学致癌物诱发大鼠肝肿瘤的影响。
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