Lascaux-Lefebvre V, Ruidavets J B, Arveiler D, Amouyel P, Haas B, Cottel D, Bingham A, Ducimetière P, Ferrières J
Department of Epidemiology, INSERM U558, Faculty of medicine, Toulouse, France.
Diabetes Metab. 2001 Sep;27(4 Pt 1):503-9.
To assess the effect of parental histories of cardiovascular risk factors on risk factor clusters (RFC) in representative samples from three French populations (MONICA centers of Lille, Strasbourg, Toulouse).
In a representative cross-sectional study, we screened 1,291 males and 1,264 females, aged 35-64 years. Subjects were defined as RFC cases when they were affected by at least 2 disorders among, hypertension (systolic or diastolic blood pressure >=140/90 mmHg and/or antihypertensive drug), diabetes (physician-diagnosed diabetes and/or glycemia >=7.0 mmol/l and/or hypoglycemic drug), and dyslipidemia (triglycerides > 2.26 mmol/l and/or HDL-cholesterol<0.9 mmol/l in men and<1.2 mmol/l in women). Nineteen percent of the subjects were RFC cases. Parental histories of cardiovascular risk factors (hypertension, diabetes, hyperlipidemia) were positive if they were under 65. About 29% of the subjects had at least one parental history of risk factor.
After adjustment for sex, age, educational level, sedentary lifestyle, alcohol consumption, body mass index, LDL cholesterol and center, parental histories of cardiovascular risk factors were significantly associated with the RFC. One, two, or at least three parental histories were significantly associated with increased odds of being RFC cases (adjusted OR 1.39 95% CI [1.05-1.82], 2.90 95% CI [1.91-4.40], 2.93 95% CI [1.41-6.08]). Furthermore, a maternal-only history vs a paternal-only history of hypertension or diabetes was associated with strong odds of being an RFC case.
At least a single cardiovascular risk factor in parents was significantly associated with RFC in offspring, independently of environmental parameters.
评估心血管危险因素的家族史对来自法国三个群体（里尔、斯特拉斯堡、图卢兹的莫尼卡中心）代表性样本中危险因素聚集（RFC）的影响。
在一项代表性横断面研究中，我们筛查了1291名男性和1264名年龄在35 - 64岁之间的女性。当受试者受到以下至少2种疾病影响时被定义为RFC病例：高血压（收缩压或舒张压≥140/90 mmHg和/或使用降压药）、糖尿病（医生诊断的糖尿病和/或血糖≥7.0 mmol/l和/或使用降糖药）以及血脂异常（男性甘油三酯>2.26 mmol/l和/或高密度脂蛋白胆固醇<0.9 mmol/l，女性<1.2 mmol/l）。19%的受试者为RFC病例。如果父母在65岁以下，心血管危险因素（高血压、糖尿病、高脂血症）的家族史为阳性。约29%的受试者至少有一项危险因素的家族史。
在对性别、年龄、教育水平、久坐不动的生活方式、饮酒量、体重指数、低密度脂蛋白胆固醇和中心进行调整后，心血管危险因素的家族史与RFC显著相关。有一项、两项或至少三项家族史与成为RFC病例的几率增加显著相关（调整后的比值比1.39，95%置信区间[1.05 - 1.82]；2.90，95%置信区间[1.91 - 4.40]；2.93，95%置信区间[1.41 - 6.08]）。此外，仅母亲有高血压或糖尿病家族史与仅父亲有家族史相比，成为RFC病例的几率更高。
父母中至少有一项心血管危险因素与后代的RFC显著相关，且独立于环境参数。
