Mirmiran P, Esmaillzadeh A, Azizi F
1Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Eur J Clin Nutr. 2004 Aug;58(8):1110-8. doi: 10.1038/sj.ejcn.1601936.
To determine optimal cutoff points of anthropometric measures as cardiovascular indicators in an Iranian adult population.
: Population-based cross-sectional study.
Tehran, the capital of Iran.
A total of 10 522 subjects (4449 men and 6073 women) aged 18-74 y.
Demographic data were collected and anthropometric indices were measured. Blood pressure was evaluated and hypertension was defined based on JNC VI. Biochemical measurements were done. Diabetes was considered as FBS> or =126 mg/dl (> or =7.0 mmol/l) and dyslipidemia was defined according to ATP II. Risk factors were considered as: hypertension, diabetes, dyslipidemia, 'hypertension or diabetes', 'hypertension and diabetes', 'hypertension or dyslipidemia', 'hypertension and dyslipidemia', ' diabetes or dyslipidemia', 'diabetes and dyslipidemia', 'at least one risk factor' and 'at least two risk factors'. ROC curve analysis was performed to determine optimal cutoff values-where the sensitivity approximates specificity.
Younger men (the age category of 18-34 y) had higher WC than women. Men had higher waist-to-hip ratio (WHpR) and lower waist-to-height ratio (WHtR) than women in all age categories. Dyslipidemia, 'hypertension or dyslipidemia', 'diabetes or dyslipidemia' and 'at least one risk factor' were more prevalent risk categories in both genders. Range of areas under ROC curves for BMI and WC was 0.55-0.94 and 0.56-0.93 for men and 0.41-0.94 and 0.53-0.92 for women in various age groups, respectively. Range of areas for WHpR and WHtR in men was between 0.58-0.87 and 0.56-0.94, respectively, and for women varied between 0.53-0.91 and 0.53-0.90 in various age groups, respectively. Cutoff points of BMI for various risk factors were between 24 and 29 kg/m(2) in men and 25-31 kg/m(2) in women. Range of WHpR was between 0.86 and 0.97 in men and between 0.78 and 0.92 in women. Cutoff points for WC and WHtR were between 80 and 93 cm and 0.47 and 0.56 for men and between 79 and 96 cm and 0.50 and 0.63 for women in different age groups to detect various risk factors, respectively. In general, values were lowest for the most prevalent risk factors and highest for less prevalent conditions.
The results suggested cutoff points of anthropometric measures as indicators of cardiovascular risk factors. It seems that these cut-points are higher for Iranians than for other Asian populations.
Endocrine Research Center, Shaheed Beheshti University of Medical Sciences.
确定在伊朗成年人群体中作为心血管指标的人体测量指标的最佳切点。
基于人群的横断面研究。
伊朗首都德黑兰。
总共10522名年龄在18 - 74岁的受试者（4449名男性和6073名女性）。
收集人口统计学数据并测量人体测量指标。评估血压并根据美国国家联合委员会第六版（JNC VI）定义高血压。进行生化测量。糖尿病定义为空腹血糖（FBS）≥126 mg/dl（≥7.0 mmol/l），血脂异常根据成人治疗小组第三次报告（ATP III）定义。危险因素包括：高血压、糖尿病、血脂异常、“高血压或糖尿病”、“高血压和糖尿病”、“高血压或血脂异常”、“高血压和血脂异常”、“糖尿病或血脂异常”、“糖尿病和血脂异常”、“至少一种危险因素”以及“至少两种危险因素”。进行ROC曲线分析以确定最佳切点值，即敏感性近似于特异性的点。
较年轻的男性（18 - 34岁年龄组）腰围高于女性。在所有年龄组中，男性的腰臀比（WHpR）高于女性，腰高比（WHtR）低于女性。血脂异常、“高血压或血脂异常”、“糖尿病或血脂异常”以及“至少一种危险因素”在两性中都是更普遍的危险因素类别。在不同年龄组中，男性BMI和WC的ROC曲线下面积范围分别为0.55 - 0.94和0.56 - 0.93，女性分别为0.41 - 0.94和0.53 - 0.92。男性WHpR和WHtR的面积范围分别在0.58 - 0.87和0.56 - 0.94之间，女性在不同年龄组中分别在0.53 - 0.91和0.53 - 0.90之间。男性不同危险因素的BMI切点在24至29 kg/m²之间，女性在25 - 31 kg/m²之间。男性WHpR范围在0.86至0.97之间，女性在0.78至0.92之间。不同年龄组中男性WC和WHtR检测各种危险因素的切点分别在80至93 cm和0.47至0.56之间，女性在79至96 cm和0.50至0.63之间。一般来说，最普遍危险因素的数值最低，较不普遍情况的数值最高。
结果表明人体测量指标的切点可作为心血管危险因素的指标。似乎这些切点对于伊朗人而言高于其他亚洲人群。
谢赫·贝赫什提医科大学内分泌研究中心。
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