Influence of anticoagulant substances on phosphoserine and taurine of human blood.

The influence of heparine (Liquemin) and sodium-EDTA on phosphoserine and taurine of human blood was investigated. Phosphoserine which was not or nearly not present in serum increased after addition of both the anticoagulant substances. The heparine used contained phosphoserine as the only ninhydrinic substance in low concentrations. After addition of heparine phosphoserine in human plasma does not increase proportionally to that change. A mechanism is assumed which leads to the release from cells or which stimulates the synthesis of the substance. A similar effect was found with sodium-EDTA but not with sodium citrate. An opposite effect was detected with taurine in human blood. In serum the highest concentration was measured which decreased slowly under heparine as well as under sodium-EDTA addition.