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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Ariyoshi T, Arakaki M, Ideguchi K, Ishizuka Y, Noda K

Xenobiotica. 1975 Jan;5(1):33-8. doi: 10.3109/00498257509056091.

After a single oral dose of d-limonene (200-1200 mg/kg) no effects were observed on liver triglyceride, microsomal protein, cytochrome b5, and the drug-metabolizing enzymes. Glycogen content was slightly decreased at doses higher than 800 mg/kg, and cytochrome P-450 and delta-aminolaevulinic acid synthetase activity was slightly increased at 1200 mg/kg. 2. After repeated treatment (400 mg/kg/day) for 30 days, the relative liver weight and hepatic phospholipid content were only slightly increased, and liver and serum cholesterol were decreased 49 and 8%, respectively. Of the phospholipid fatty acids, palmitic, linoleic and arachidonic acids were increased, and stearic acid was decreased. Aminopyrine demethylase and aniline hydroxylase were increased 26 and 22%, respectively, and cytochrome P-450 and b5 were likewise increased 31 and 30%.

单次口服d-柠檬烯（200 - 1200毫克/千克）后，未观察到对肝脏甘油三酯、微粒体蛋白、细胞色素b5和药物代谢酶有任何影响。在剂量高于800毫克/千克时，糖原含量略有下降，在1200毫克/千克时，细胞色素P - 450和δ-氨基乙酰丙酸合成酶活性略有增加。2. 经30天重复治疗（400毫克/千克/天）后，相对肝脏重量和肝脏磷脂含量仅略有增加，肝脏和血清胆固醇分别下降了49%和8%。在磷脂脂肪酸中，棕榈酸、亚油酸和花生四烯酸增加，硬脂酸减少。氨基比林脱甲基酶和苯胺羟化酶分别增加了26%和22%，细胞色素P - 450和b5同样分别增加了31%和30%。

Ariyoshi T, Arakaki M, Ideguchi K, Ishizuka Y, Noda K

Xenobiotica. 1975 Jan;5(1):33-8. doi: 10.3109/00498257509056091.

After a single oral dose of d-limonene (200-1200 mg/kg) no effects were observed on liver triglyceride, microsomal protein, cytochrome b5, and the drug-metabolizing enzymes. Glycogen content was slightly decreased at doses higher than 800 mg/kg, and cytochrome P-450 and delta-aminolaevulinic acid synthetase activity was slightly increased at 1200 mg/kg. 2. After repeated treatment (400 mg/kg/day) for 30 days, the relative liver weight and hepatic phospholipid content were only slightly increased, and liver and serum cholesterol were decreased 49 and 8%, respectively. Of the phospholipid fatty acids, palmitic, linoleic and arachidonic acids were increased, and stearic acid was decreased. Aminopyrine demethylase and aniline hydroxylase were increased 26 and 22%, respectively, and cytochrome P-450 and b5 were likewise increased 31 and 30%.

单次口服d-柠檬烯（200 - 1200毫克/千克）后，未观察到对肝脏甘油三酯、微粒体蛋白、细胞色素b5和药物代谢酶有任何影响。在剂量高于800毫克/千克时，糖原含量略有下降，在1200毫克/千克时，细胞色素P - 450和δ-氨基乙酰丙酸合成酶活性略有增加。2. 经30天重复治疗（400毫克/千克/天）后，相对肝脏重量和肝脏磷脂含量仅略有增加，肝脏和血清胆固醇分别下降了49%和8%。在磷脂脂肪酸中，棕榈酸、亚油酸和花生四烯酸增加，硬脂酸减少。氨基比林脱甲基酶和苯胺羟化酶分别增加了26%和22%，细胞色素P - 450和b5同样分别增加了31%和30%。