Igimi H, Hisatsugu T, Nishimura M
Am J Dig Dis. 1976 Nov;21(11):926-39. doi: 10.1007/BF01071903.
The dissolving mixture is administered through a choledochal drain to treat postoperatively retained cholesterol gallstones. It is prepared by mixing 97.0 parts of d-limonene with 2.1 parts of polysorbate 80 and 0.9 part of sorbitan monooleate, a mixture of which may easily reach the surface of the gallstones which are wetted by bile. The d-limonene preparation was found to be safe both in laboratory experiments and clinical trials. Before applying the preparation, the usual choledochal drain must be replaced with a recently developed catheter made from epichlorohydrine rubber, which is chemically resistant to the preparation. Three cases of retained gallstones are described where the preparation was successfully used. In the fourth case treatment with the preparation was tried in lieu of surgery but was not successful due to other complications. However, some dissolution of retained stones was observed. There were no postoperative complaints in the long-term follow-up of some cases for more than 2 yr after treatment with the preparation. This procedure promises to be of value because retained cholesterol stones may be dissolved without the necessity of further surgery.
溶解混合物通过胆总管引流管给药，用于治疗术后残留的胆固醇结石。它是由97.0份d-苎烯与2.1份聚山梨酯80和0.9份脱水山梨醇单油酸酯混合而成，该混合物很容易到达被胆汁浸湿的胆结石表面。在实验室实验和临床试验中，d-苎烯制剂均被证明是安全的。在应用该制剂之前，必须将常用的胆总管引流管换成最近开发的由环氧氯丙烷橡胶制成的导管，该导管对该制剂具有化学耐受性。文中描述了3例成功使用该制剂的残留胆结石病例。在第4例中，尝试用该制剂替代手术治疗，但由于其他并发症未成功。然而，观察到残留结石有一定程度的溶解。在一些病例中，用该制剂治疗后进行了超过2年的长期随访，未出现术后不适。该方法有望具有价值，因为残留的胆固醇结石无需进一步手术即可溶解。
