眼部整形手术后的化脓性肉芽肿：血管生成调节失衡？
Pyogenic granuloma following oculoplastic procedures: an imbalance in angiogenesis regulation?
作者信息
Jordan D R, Brownstein S, Lee-Wing M, Ashenhurst M
机构信息
Department of Ophthalmology, University of Ottawa Eye Institute, Ont.
出版信息
Can J Ophthalmol. 2001 Aug;36(5):260-8. doi: 10.1016/s0008-4182(01)80019-3.
BACKGROUND
Pyogenic granuloma is a vasoproliferative inflammatory response composed of granulation tissue. The pathogenesis is not entirely clear. We describe a series of patients with pyogenic granulomas occurring following common oculoplastic procedures and propose a common etiology.
METHODS
Sixteen cases of pyogenic granuloma that occurred after various oculoplastic procedures from 1991 to 2000 were collected from the files of two oculoplastic surgeons.
RESULTS
Pyogenic granulomas were found to occur at surgical and nonsurgical sites associated with tissue irritation or inflammation or both.
INTERPRETATION
Capillaries are a predominant component of wound healing and pyogenic granulomas. The growth and development of new capillaries follows an orderly sequence of events that is highly regulated by a variety of angiogenic factors. We postulate an imbalance in angiogenesis regulation as the common pathway for pyogenic granuloma development.
背景
化脓性肉芽肿是一种由肉芽组织构成的血管增生性炎症反应。其发病机制尚不完全清楚。我们描述了一系列在常见眼部整形手术后发生化脓性肉芽肿的患者，并提出了一个共同的病因。
方法
从两位眼部整形外科医生的档案中收集了1991年至2000年间在各种眼部整形手术后发生的16例化脓性肉芽肿病例。
结果
发现化脓性肉芽肿发生在与组织刺激或炎症或两者相关的手术和非手术部位。
解读
毛细血管是伤口愈合和化脓性肉芽肿的主要组成部分。新毛细血管的生长和发育遵循一系列由多种血管生成因子高度调节的有序事件。我们推测血管生成调节失衡是化脓性肉芽肿发展的共同途径。
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