Sapegin I D
Pharmacology Department, Clinical Immunology and Allergology Department (with Clinical Pharmacology Faculty), Simferopol State Medical University, Lenin bul. 5/7, Simferopol, Crimea, Ukraine.
Eksp Klin Farmakol. 2001 Mar-Apr;64(2):35-7.
Chronic experiments on conscious rabbits with needle electrodes implanted into cortex, thalamus, and hypothalamus were used to study variations in the local blood flow (BF) and the cerebral vessel response to hypercapnia and hyperoxia by method of hydrogen clearance. Variations of the partial oxygen pressure (PO2) in the tissues of these structures was measured by the polarographic technique. The general vibration action (modeled in a special testing device) decreased the local BF in the cortex and hipothalamus, suppressed the response of cerebral vessel (especially of the constrictor ones) to hyperoxia, and reduced PO2 in all the structures studied. Acting upon the neuron energy exchange and reducing their oxygen consumption, thiotriazolin prevented the drop in PO2 and even increased this parameter, while not preventing the decrease in BF and the inhibition of vessel response.
采用将针电极植入清醒家兔的皮层、丘脑和下丘脑进行慢性实验，通过氢清除法研究局部血流量（BF）变化以及脑血管对高碳酸血症和高氧的反应。采用极谱技术测量这些结构组织中的局部氧分压（PO2）变化。一般振动作用（在特殊测试装置中模拟）可降低皮层和下丘脑的局部BF，抑制脑血管（尤其是收缩血管）对高氧的反应，并降低所有研究结构中的PO2。噻三唑啉作用于神经元能量交换并降低其耗氧量，可防止PO2下降甚至增加该参数，同时不阻止BF下降和血管反应的抑制。
