Nanto S, Masuyama T, Takano Y, Hori M, Nagata S
Cardiovascular Division of Kansai Rosai Hospital, Amagasaki, Japan.
Jpn Circ J. 2001 Sep;65(9):793-6. doi: 10.1253/jcj.65.793.
The present study seeks to estimate the difference between coronary zero flow pressure (Pzf) by analysis of the baseline pressure-flow relationship and the Pzf calculated during a long diastole in humans. Although Pzf is likely to provide meaningful information about the characteristics of coronary circulation, there are no available data on Pzf in humans because Pzf is overestimated when it is calculated during normal cardiac cycles. Actual Pzf was determined in 15 subjects by analyzing the coronary pressure-flow relationship during a long cardiac cycle induced by an intracoronary adenosine triphosphate (ATP) infusion, and it was compared with the Pzf calculated during a normal cardiac cycle in order to estimate the difference. Pzf calculated during a normal cardiac cycle was 47 +/- 15 mmHg, which decreased to 36 +/- 9mmHg after intracoronary administration of ATP (0.05 mg) whereas actual Pzf was 21 +/- 7 mmHg. Pzf calculated in a pressure-flow relationship during a normal cardiac cycle under vasodilation correlated well with that during a long diastole (r = 0.75, p < 0.01), although it was 15 +/- 6 mmHg greater than the actual Pzf. It was concluded that Pzf during a normal cardiac cycle could be used to anticipate Pzf.
本研究旨在通过分析基线压力-流量关系来估计冠状动脉零流量压力（Pzf）与人类长舒张期计算所得的Pzf之间的差异。尽管Pzf可能会提供有关冠状动脉循环特征的有意义信息，但由于在正常心动周期计算Pzf时会高估，因此尚无关于人类Pzf的可用数据。通过分析冠状动脉内输注三磷酸腺苷（ATP）诱发的长心动周期中的冠状动脉压力-流量关系，在15名受试者中确定了实际Pzf，并将其与正常心动周期计算所得的Pzf进行比较以估计差异。正常心动周期计算所得的Pzf为47±15 mmHg，冠状动脉内给予ATP（0.05 mg）后降至36±9 mmHg，而实际Pzf为21±7 mmHg。尽管在血管舒张状态下正常心动周期的压力-流量关系中计算所得的Pzf比实际Pzf大15±6 mmHg，但二者与长舒张期计算所得的Pzf相关性良好（r = 0.75，p <0.01）。得出的结论是，正常心动周期的Pzf可用于预测Pzf。
