Werner H, Egger I
Zentralbl Bakteriol Orig A. 1975;231(1-3):349-64.
In the present paper, the efficacy of different sulphonamides and potentiators alone and in combination (BACTRIM, FANSIDAR) in mice infected with Toxoplasma gondii is evaluated. The experimental chemotherapeutical studies were performed in mice either freshly infected with trophozoites or cystozoites, or suffering from acute disease or a chronic infection; For the components (see article) a proportion of 10 times 1 turned out to be the most effective mixing ratio. In comparison with the standard combination of sulphamethoxypyrazine times pyrimethamine sharing the best degree of activity, the therapeutic effect of a combination of sulphadoxine times pyrimethamine (components of FANSIDAR) in a proportion of 20 times 1 was either the same or less, depending on the experimental design. The duration of therapy was found to be decisive for the therapeutic result. If it is too short the parasite will return to the cyst stage; Even at low dosage, the components of FANSIDAR, sulphadoxine and pyrimethamine in combination, are capable of acting upon all forms of the proliferative multiplication phase and the cyst formation phase, inclusive of young cysts, and eliminated them completely from the host organism.
在本论文中，评估了不同磺胺类药物及其增效剂单独使用以及联合使用（复方新诺明、 Fansidar）对感染刚地弓形虫小鼠的疗效。实验性化疗研究在刚感染滋养体或包囊体的小鼠、患有急性疾病或慢性感染的小鼠中进行；对于各组分（见文章），结果表明10倍1的比例是最有效的混合比例。与具有最佳活性程度的磺胺甲氧嗪与乙胺嘧啶标准组合相比，磺胺多辛与乙胺嘧啶（Fansidar的组分）按20倍1比例组合的治疗效果根据实验设计要么相同要么更低。发现治疗持续时间对治疗结果起决定性作用。如果时间过短，寄生虫会回到包囊阶段；即使剂量较低，Fansidar的组分磺胺多辛和乙胺嘧啶联合使用也能够作用于增殖繁殖阶段和包囊形成阶段的所有形式，包括幼龄包囊，并将它们从宿主体内完全清除。
