Chemotherapy in experimental toxoplasmosis: comparison of the efficacy of trimethoprim-sulfur and pyrimethamine-sulfur combinations.

Mice infected by intraperitoneal inoculation of the RH strain of Toxoplasma gondii were treated with various drugs. Trimethoprim was found to have no effect. Sulphamethoxazole, sulphadiazine and pyrimethamine had significant therapeutic effects on the course of murine toxoplasmosis. The therapeutic efficacy of sulphamethoxazole was enhanced by the addition of trimethoprim. A pyrimethamine-sulphadiazine combination was found to be superior to a trimethoprim-sulphamethoxazole combination in the treatment of experimental murine toxoplasmosis.