Jevtovic-Todorovic V, Wozniak D F, Powell S, Olney J W
Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Avenue, P.O. Box 8054, St. Louis, MO 63110, USA.
Brain Res. 2001 Sep 21;913(2):185-9. doi: 10.1016/s0006-8993(01)02800-1.
N-Methyl-D-aspartate (NMDA) antagonists act by an anti-excitotoxic action to provide neuroprotection against acute brain injury, but these agents can also cause toxic effects. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. GABAmimetic drugs protect against the reversible neurotoxic changes in rat brain. Here we show that two GABAmimetic anesthetic agents--propofol and sodium thiopental--protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801.
N-甲基-D-天冬氨酸（NMDA）拮抗剂通过抗兴奋性毒性作用来为急性脑损伤提供神经保护，但这些药物也会产生毒性作用。低剂量时，它们会引起可逆性神经元损伤，但高剂量时会导致大脑皮质神经元发生不可逆的变性。拟γ-氨基丁酸（GABA）类药物可预防大鼠脑中可逆性神经毒性变化。在此，我们表明两种拟GABA类麻醉剂——丙泊酚和硫喷妥钠——可预防由强效NMDA拮抗剂MK-801诱导的不可逆神经退行性反应。
