Pérez-Neri Iván, Ramírez-Bermúdez Jesús, Montes Sergio, Ríos Camilo
Department of Neurochemistry, National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877 Col. La Fama. Tlalpan, 14269, Mexico City, Mexico.
Neurochem Res. 2006 Oct;31(10):1279-94. doi: 10.1007/s11064-006-9162-3. Epub 2006 Sep 28.
Brain morphological alterations in schizophrenic patients have led to the neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive neurodegenerative process has also been suggested and some follow-up studies have shown progressive morphological changes in schizophrenic patients. Several neurotransmitter systems have been suggested to be involved in this disorder and some of them could lead to neuronal death under certain conditions. This review discusses some of the biochemical pathways that could lead to neurodegeneration in schizophrenia showing that neuronal death may have a role in the etiology or natural course of this disorder.
精神分裂症患者的脑形态学改变引发了精神分裂症的神经发育假说。另一方面，也有人提出存在进行性神经退行性变过程，一些随访研究显示精神分裂症患者存在进行性形态学变化。有几种神经递质系统被认为与这种疾病有关，其中一些在某些情况下可能导致神经元死亡。本综述讨论了一些可能导致精神分裂症神经退行性变的生化途径，表明神经元死亡可能在这种疾病的病因或自然病程中起作用。
