van der Stege J G, van der Linden P J
Department of Obstetrics and Gynaecology, Academisch Ziekenhuis Groningen, The Netherlands.
Gynecol Obstet Invest. 2001;52(1):43-6. doi: 10.1159/000052939.
Eighty-seven patients undergoing in vitro fertilization were studied to evaluate the prognostic value of different tests in predicting ovarian stimulation response. We studied basal follicle-stimulating hormone (FSH) value on cycle day 3, the clomiphene citrate (CC) challenge test and serum estradiol levels on cycle day 3. Patients with elevated basal FSH levels needed more ampoules of gonadotropins for stimulation and had a higher cancellation rate because of poor response. Patients with abnormal CC challenge test results also needed more ampoules of gonadotropins, but the higher cancellation rate in this group did not reach statistical significance. The basal estradiol level did not contribute to further discrimination between groups. We conclude that basal FSH level on cycle day 3 is a useful prognosticator of ovarian stimulation response.
对87名接受体外受精的患者进行了研究，以评估不同检测方法在预测卵巢刺激反应方面的预后价值。我们研究了周期第3天的基础卵泡刺激素（FSH）值、枸橼酸氯米芬（CC）激发试验以及周期第3天的血清雌二醇水平。基础FSH水平升高的患者在刺激时需要更多支促性腺激素，且由于反应不佳而取消治疗的比例更高。CC激发试验结果异常的患者也需要更多支促性腺激素，但该组较高的取消治疗率未达到统计学意义。基础雌二醇水平对区分不同组没有进一步帮助。我们得出结论，周期第3天的基础FSH水平是卵巢刺激反应的一个有用的预后指标。
